In vivo 31P MRS

In vivo ³¹P MRS is sensitive in detecting changes during development in the molecular biochemistry of cortex that reflects neuropil expansion/contraction by measuring precursors of membrane phospholipids (MPLs) [phosphocholine (PC); phoshoethanolamine (PE)]. In these publications, I was the first to report subcortical/cortical deficits in MPL precursor levels of ADHD children that are suggestive of an alteration of an earlier developing region potentially influencing the maturational integration of later developing regions. Publications:
  1. Stanley JA, Wu H, Goradia DD, Khatib D, Rajan U, Burgess A, Robin AL, Rosenberg DR.  Evidence of Altered Neuropil Development in ADHD children: A Longitudinal in vivo ³¹P MRS Study at 3 Tesla. Biological Psychiatry. May 2015; 77: S-108S.
  2. Stanley JA, Kipp H, Greisenegger E, Macmaster FP, Panchalingam K, Keshavan MS, Bukstein OG and Pettegrew JW. Evidence of Developmental Alterations in Cortical and Subcortical Regions of Children with ADHD: A Multi-voxel In Vivo 31P Spectroscopy Study. Arch. Gen. Psychiatry, 2008, 65:1419-28.
  3. Stanley JA, Kipp H, Greisenegger K, Panchalingam K, Pettegrew JW, Keshavan MS, Bukstein OG.  Regionally specific alterations in membrane phospholipids in children with ADHD: an in vivo 31P spectroscopy study. Psychiatry Research 2006; 148:217-221