Title: Task-related modulation of hippocampal glutamate, subfield volumes, and associative memory in younger and older adults: A longitudinal ¹H fMRS study

PI Name: Dr. Jeffery Stanley,
Department of Psychiatry and Behavioral Neurosciences
Wayne State University

Personal website: psychiatry.med.wayne.edu/research.php

¹H fMRS is becoming a well-established technique that is sensitive to measuring task-related and pathology-relevant regional dynamic changes in neurotransmitters such as glutamate. The observed task-related changes in brain glutamate are consistent with new metabolic steady states reflecting the neural output driven by shifts in the local excitatory and inhibitory balance on local circuits. This research has recently published studies demonstrating increased modulation of glutamate during a working memory task as well as differences in steady-state glutamate levels and variability between tasks of varying constraints on behavior.

  1. Woodcock EA*, Anand C, Khatib D, Diwadkar VA, Stanley JA. Working Memory Modulates Glutamate Levels in the Dorsolateral Prefrontal Cortex during ¹H fMRS. Frontiers in Psychiatry: Neuroimaging and Stimulation. 2018, 9 (66):1-10.
  2. Lynn J*, Woodcock EA, Anand C, Khatib D, Stanley JA. Differences in steady-state glutamate levels and variability between ‘non-task-active’ conditions: Evidence from ¹H fMRS of the prefrontal cortex. NeuroImage. 2018, 172: 554-561.